Ticlopidine is used to lessen the occurrence of cerebrovascular accidents( CVA). It is given to those with a history of stroke. Because ticlopidine can cause serious side effects, especially during the first 3 months of treatment, it is used mostly for people who cannot take aspirin to prevent strokes. Ticlopidine reduces the chances of thrombus formation, by preventing platelets from aggregating.

Oral dosage form (tablets): For prevention of strokes: Adults: 1 tablet (250 mg) two times a day with food.

Contra Indications

Contraindication to Ticlopidine are pregnancy, lactation, acute phase of haemorrhagic cerebrovascular accident, neutropenia, thrombocytopenia and hypersensitivity.

Precautions

Precaution should be taken in Coagulation defects ( such as hemophilia and Von Willebrand's disease) and Hepatic disease. Gastric ulcers: the chances of serious bleeding may be increased. In Renal Impairment Ticlopidine is excreted from the body more slowly, which may increase the chance of adverse effects.

Interactions

The chance of serious bleeding may be increased with: Anticoagulants, Carbenicillin, Dipyridamole, Divalproex, Heparin, Anti-inflammatory drugs, Pentoxifylline, Plicamycin, Sulfinpyrazone, Ticarcillin and with Valproic acid.

Brand Names

Blothin ( Indipharma), Ticlop (Cadila Healthcare), Ticlovas (USV), Tikleen (IPCA), Ticlon (FDC), Tyklid (Torrent ).

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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