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  Terbutaline

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Respiratory, systemic
Category Bronchodilator


Pharmacokinetics

It is a selective Beta-2 adrenoreceptor agonist. It is a potent bronchodilator. It can be given both orally as well as parentrally. It is not a substrate for COMT, hence it has a long duration of action of about 4-8 hours.



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Indications

They are taken by oral inhalation and parentrally for relief of bronchospasm in asthma, chronic bronchitis and emphysema.



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Routes of Administration and Dosage

Inhalation aerosol dosage in Adults : 80 to 240 mg t.i.d or 13 mg /kg /day in divided doses upto a max of 900mg / day.In children 1 to 9 yrs 24 mg / kg/day in divided doses. Parentral dose for acute asthmatic attacks and narrowing of airways:Aminophyl



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Contra Indications

The drug is contraindicated in persons with hypersensitivity to xanthine derivatives, in neonates and during lactation.



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Precautions

Precautions to be taken in patients with Brain damage, Convulsions, Diabetes mellitus, Cardiac disease,Hypertension, Hepatic dysfunction, Hyperthyroidism, Peptic ulcer,Pregnancy and Pulmonary oedema.



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Interactions

Beta-blockers : These drugs reduce the effect of the adrenergic bronchodilators. Cocaine, Ergoloid mesylates, Ergotamine, Maprotiline, Tricyclic antidepressants : The effects of these drugs on the heart and blood vessels may be potentiated. Digitalis glycosides : The chance of Cardiac arrhythmias may be increased. Monoamine oxidase (MAO) inhibitors : Using adrenergic bronchodilators when using or within 2 weeks of taking monoamine oxidase (MAO) inhibitors may increase the effects of MAO inhibitors



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Brand Names

BRICANYL (ASTRA-IDL), BRICANYL DURULES (ASTRA-IDL)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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