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| Home ›› Drug Guide ››Nitrendipine |
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Nitrendipine
Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names
| Systems |
Cardiovascular System and Peripheral Vascular System
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| Category |
Calcium Channel Blocker
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Pharmacokinetics
When it is given orally has high hepatic metabolism. Hence a higher dose by oral route should be used than by I.V route. It is highly protein bound.
Indications
Nitrendipine is used to treat mild to moderate hypertension.
Routes of Administration and Dosage
For Mild to Moderate hypertension: Start with 5-20 mg once daily. May be increased to 40 mg in 1 or 2 doses. In hepatic disease reduce the dose to 5 to 10 mg daily.
Contra Indications
It is contraindicated in Hypersensitivity reaction, Acute MI, Hypotension, Lactation, Cardiogenic shock and in severe aortic stenosis.
Precautions
Allergies : Allergic reaction to nitrendipine may occur. Pregnancy: Calcium channel blockers have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blockers cause birth defects, prolonged pregnancy, poor bone development, and stillbirth. Breast-feeding : Nitrendipine passes into breast milk, but they have not been reported to cause problems in nursing babies.Older adults:- Elderly people may be especially sensitive to the effects of calcium channel blockers. This may increase the chance of side effects during treatment.
Interactions
Interaction with the following drugs have been reported: Acetazolamide, Amphotericin B, Corticosteroids, Dichlorphenamide, Diuretics, Methazolamide, Beta-blockers like acebutolol, atenolol, betaxolol, carteolol, labetalol, metoprolol, nadolol, oxprenolol, penbutolol, pindolol, propranolol, sotalol, timolol : Effects of both may be increased. In addition, adverse effects may occur if a calcium channel blocker or a beta-blocker is stopped suddenly after use together. Carbamazepine, Cyclosporine, Procainamide,Quinidine: Effects of these drugss may be increased if they are used together with calcium channel blockers. Digitalis glycosides : Effects of these drugs may be potentiated if they are used with calcium channel blockers. Disopyramide: Effects of calcium channel blockers on the heart may be potentiated.
Brand Names
Cardif (Concept), Nitrepin (USV).
Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names
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