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| Home ›› Drug Guide ›› Isosorbide Mononitrate |
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Isosorbide Mononitrate
Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names
| Systems |
Cardiovascular System
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| Category |
Anti Anginal and Coronary Vasodilator
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Pharmacokinetics
When orally given it undergoes extensive first pass metabolism hence it is administered sublingualy.
Indications
Nitrates are used to treat the symptoms of angina . Nitrates are used to treat angina in three ways: to relieve an attack that is occurring by using the drug when the attack begins; to prevent attacks from occurring by using the drug just before an attack is expected to occur; or to reduce the number of attacks that occur by using the drugs regularly on a long-term basis.
Routes of Administration and Dosage
Oral: Initially 20mg 2-3 times daily upto 120mg daily in div. doses if required.
Contra Indications
Contraindicated in Acute MI, Severe anaemia, cerebral haemorrhage, hypotension, obstructive cardiomyopathy, raised intra cranial tension and pregnancy.
Precautions
Older adults:- Dizziness or lightheadedness may be more likely to occur in the elderly. Anemia (severe) and Glaucoma: May be worsened by nitrates. In Head injury (recent) and Stroke (recent): Nitrates may increase pressure in the brain, which may lead to worsening of the condition. In recent Myocardial Infarction : Nitrates may cause hypotension, which can aggravate problems associated with MI. In renal disease and hepatic disease : Effects may be increased because of slower removal of nitroglycerin from the body.
Interactions
Orthostatic hypotension occurs when used together with: calcium channel blocker, antihypertensive, phenothiazine or tricyclic antidepressants.
Brand Names
5 Mono ( Boichem), Angiocor (Novartis), Anginex (Wyeth Lederle), Angitrit (Unisearch), IHD (Stadmed), Imdur (Astra IDL), ISMO (Boehringer Mannheim), Isocor 20 (Merck), Isotec (Sertec), Isotrim (Pace SOL), Monicor (Wallace), Monit10 (Intas), Monit 20 (Intas), Monit OD (Intas), Monn (Natco), Monocontin 50 (Modi Mundipharma), Monomen (Menarini Raunaq), Monosorbitrate (Nicholas -Piramal), Monotrate (Sun Pharma), Monotrate OD (Sun Pharma), Nitro Fix (Carsyon0, Vasonit ( Recon), Vasotrate (Torrent).
Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names
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