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  Diloxanide Furoate

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Antiprotozoal/ Luminal Amoebicide


Pharmacokinetics

Diloxanide furoate when given orally is split in the gut into diloxanide and furoic acid; the diloxanide is largely absorbed from the gut and furoic acid is esterified in the intestine. Diloxanide is glucuronidated in the liver and reaches a high level in 1hr in the plasma. The drug is excreted in the urine.



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Indications

The drug is used in intestinal amoebiasis and is given after any tissue amoebicide to eradicate cysts.



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Routes of Administration and Dosage

Oral dose (tablets): For amoebiasis in Adults and children 12 years of age and older: Oral, 500 milligrams (mg) three times a day for ten days, in Children up to 12 years of age: Dose is based on body weight. The usual dose is 20 mg per kilogram (kg) of



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Contra Indications

It is contraindicated in children below 2yrs of age.



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Precautions

Precautions to be taken in pregnancy and during lactation.Flatulence, nausea, abdominal cramps, vomiting, pruritis and urticaria are its adverse effects.



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Interactions

Interaction of Diloxanide with other drugs has not been fully studied or established.



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Brand Names

Amicline(Franco-Indian), Furamide(Knoll Pharma).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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