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Clonazepam
Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names
| Systems |
Central nervous system
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| Category |
Anti-convulsant
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Pharmacokinetics
It is absorbed from the proximal small intestine. It is extensively distributed in the body.It is 85 % bound to plasma proteins.Plasma half life averages 24 hours.It is metabolised in the liver. Clearance is reduced in liver damage.It is excreted in urine.
Indications
Clonazepam belongs to benzodiazepine group of drugs. It is used for clonic seizures, atonic seizures, temporal epilepsy, status epilepticus, infantile spasms and absence seizures.
Routes of Administration and Dosage
Oral dosage form (tablets): For control of seizures in adults : Start with 0.5 milligrams (mg) three times a day and gradually increase the dose not more than 20 mg a day. In Infants and children up to 10 years of age, the dose is based on body weight.In chidren start with 0.01 to 0.02 mgs/kg /day in divided doses and gradually increase to a maximum of 0.2 mg /kg / day.In infants the dose is 0.5 to 1mg/day.
Contra Indications
Contraindications are hypersensitivity to benzodiazepines,respiratory depression, acute pulmonary insufficiency,lactation and pregnancy.
Precautions
Allergies may occur with Clonazepam .Special precautions to be taken in elderly, chronic pulmonary insufficiency, neonates,porphyria and in patients with hepatic and renal damage.
Interactions
Adverse effects of drugs like hydantoins and phenobarbitones may be exacerbrated by clonazepam. Clonazepam potentiates the effects of alcohol.
Brand Names
Clonotril (Torrent), Lonazep (Synergy), Rivotril (Piramal Healthcare)
Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names
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