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Ceftriaxone

Systems	General (Systemic)
Category	Third Generation Cephalosporin

Pharmacokinetics

Ceftriazone is a long acting third generation cephalosporin, with half life of 8 hours. It has a good CSF penetration and eliminated equally in urine and bile.

Indications

Ceftriazone is used in bacterial meningitis[espcially in children], multi-resistant typhoid fever, complicated UTI, abdominal sepsis and septicemia. A single dose of 250 mgs I.M has proved curative in gonorrhea including PPNG.

Routes of Administration and Dosage

IN meningitis; 4gms followed by 2gms I.V[children 75-100mgs\kg] once daily for 7-10 days. Typhoid; 4gms I.V for 2 days followed by 2 gms\day[for children 75 mgs\kg] till 2 days after the fever subsides.

Contra Indications

Ceftriazone is contraindicated in patients with hypersensitivity to cephalosporins.

Precautions

Hypoprothrombinemia and bleeding are specific adverse effects of cephalosporins. Precautions are to be taken in renal failure.

Interactions

Ceftriazone gives Disulfiram like reaction with alcohol.

Brand Names

Becef(Alkem), Cefaxone IM(Lupin), Ceftrax(Dee-Pharma), Gramocer(Micro Labs), Gutencef(Merck), Inocef(J.K.Ind), Lyceft(Lyka), MonocefIV(Aristo), Monotax(Biochem), Nosocef(Merind), Odicef(Galpha), Powercef(Wockhardt), Torocef(Torrent), Traxol(Cachet Pharma), Triax( Prem Pharma), Zefone(Cadila Healthcare).