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  Vitamin E (Alpha-Tocopherol)

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Fat soluble vitamin.


Pharmacokinetics

It is absorbed from the intestine through lymph. It circulates through the body plasma in association with Beta-lipoprotien. It is stored in the tissues and excreted as metabolites in the bile and urine.



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Indications

Vitamin E is necessary in small amounts and is available in common foodstuffs like green leafy vegetables. Vitamin E prevents chemical oxidation, hence it acts mainly as an antioxidant. It is also important for the proper function of nerves and muscles. Vitamin E requirements are increased in intestinal disease, hepatic disease, pancreatic disorders and surgical removal of stomach. Prolonged treatment with vitamin E increases the survival time of erythrocytes in G-6-PD deficiency. The risk of retrolental fibroplasia in infants exposed to high concentrations of oxygen can be reduced by oral vitamin E.



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Routes of Administration and Dosage

Supplemental doses 10-30 mg/day may be given to patients at risk of developing deficiency. To increase the survival time of erythrocytes in G-6-PD deficiency: 100 mg/day of vitamin E should be given.The risk of retrolental fibroplasia in infants exposed t



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Contra Indications

Vitamin E may be contraindicated in Bleeding disorders. It should not be administered I.V.



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Precautions

Hypersensitivity reactions to the drug may occur. Precautions must be taken when taking the drug during pregnancy and breast-feeding.



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Interactions

Interactions to this drug are usually rare. High doses potentiate the anticoagulant action of Warfarin.



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Brand Names

COVITA (NEO PHARMA), ECAP (GLENMARK), EVION (MERCK), EVIT 200/400 (ABBOTT), NATVIE (FRANCO-INDIAN), VITEOLIN (GLAXO ALLENBURYS)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


 

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