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  Ticlopidine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Cardiovascular System
Category Platelet Aggregation Inhibitor


Pharmacokinetics

When Ticlopidine is given orally it inhibits platelet aggregation induced by adenosine diphospate. It does not inhibit via cyclo-oxygenase pathway.



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Indications

Ticlopidine is used to lessen the occurrence of cerebrovascular accidents( CVA). It is given to those with a history of stroke. Because ticlopidine can cause serious side effects, especially during the first 3 months of treatment, it is used mostly for people who cannot take aspirin to prevent strokes. Ticlopidine reduces the chances of thrombus formation, by preventing platelets from aggregating.



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Routes of Administration and Dosage

Oral dosage form (tablets): For prevention of strokes: Adults: 1 tablet (250 mg) two times a day with food.



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Contra Indications

Contraindication to Ticlopidine are pregnancy, lactation, acute phase of haemorrhagic cerebrovascular accident, neutropenia, thrombocytopenia and hypersensitivity.



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Precautions

Precaution should be taken in Coagulation defects ( such as hemophilia and Von Willebrand's disease) and Hepatic disease. Gastric ulcers: the chances of serious bleeding may be increased. In Renal Impairment Ticlopidine is excreted from the body more slowly, which may increase the chance of adverse effects.



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Interactions

The chance of serious bleeding may be increased with: Anticoagulants, Carbenicillin, Dipyridamole, Divalproex, Heparin, Anti-inflammatory drugs, Pentoxifylline, Plicamycin, Sulfinpyrazone, Ticarcillin and with Valproic acid.



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Brand Names

Blothin ( Indipharma), Ticlop (Cadila Healthcare), Ticlovas (USV), Tikleen (IPCA), Ticlon (FDC), Tyklid (Torrent ).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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