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  Phenylbutazone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Musculoskeletal system
Category NSAID-Pyrazolone derivative.


Pharmacokinetics

Phenylbutazone is completely absorbed orally. When given IM, it binds to the local tissue protein and also causes local damage. When given orally the drug is completely absorbed. It is 98% plasma protein bound. It is metabolised in the liver by hydroxylation and glucuronidation. The plasma halflife is about 60 hrs.



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Indications

Phenylbutazone is used in acute exacerbations of rheumatoid arthritis and ankylosing spondylitis. It is also used to suppress attacks of acute gout.



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Routes of Administration and Dosage

For oral dosage forms (capsules, tablets, and buffered tablets): For severe arthritis in Adults and teenagers over 15 years of age : initially 100 milligrams (mg) three or four times a day. A higher dose of 200 mg three times a day may be needed in sever



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Contra Indications

Phenylbutazone is contraindicated in hypertention, CHF, hypersensitivity, active peptic ulcer, liver, kidney, thyroid diseases and in blood dyscrasias.



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Precautions

Precaution has to be taken in dyspepsia, hypertention and in lactation.



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Interactions

Phenylbutazone potentiates the action of anticoagulants like warfarin and oral hypoglycaemic agents. It increases the toxicity of Methotrexate by reducing its renal clearance and displacing it from it plasma proteins. Phenylbutazone also inhibits the metabolism of Phenytoin and also reduces the hypotensive effect of beta-blockers.



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Brand Names

Zolandin(SPPL).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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