Welcome, Guest    Sign in to Windows Live ID | Register  

  Industry Medical Portal |  Student Centre |  Sitemap |  Help 
FAQAbout Us |  Disclaimer & Legal |  Contact Us 

  Phenobarbitone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Central Nervous System
Category Barbiturate(Anti convulsant. )


Pharmacokinetics

Phenobarbitone has slow oral absorption and a long plasma half life[80-120 hours]. The plasma protien binding is 40-60%. It is metabolised in the liver as well as excreted unchanged by the kidneys.



Top

Indications

Phenobarbitone is used as anticonvulsant to help control seizures in grand mal epilepsy, cortical focal seizures and in status epilepticus.Phenobarbitone is not effective in petitmal and psychomotor epilepsy. Phenobarbitone has been used to treat insomnia, but if used regularly for insomnia, they are usually not effective for longer than a few weeks.



Top

Routes of Administration and Dosage

Oral:60 mgs 1-3 times a day in adults, 3-6 mgs/kg/day in children. Parenteral: 50-200 mgs I.M or I.V, repeated after 6 hours if required[Maximum 600 mg/day].



Top

Contra Indications

Contraindicated in acute intermittent porphyria, hepatic & renal disease and severe myocardial damage..



Top

Precautions

Special precautions have to be taken when phenobarbitone is given to the elderly and to pregnant women.



Top

Interactions

Phenobarbitone is a hepatic drug inducer hence metabolism of many drugs are accelerated. Phenobarbitone decreases the effects of adrenocorticoids, anticoagulants, carbamazepine and oral contraceptives. It has additive sedative effect with alcohol and other CNS depressants.



Top

Brand Names

Gardenal (RHONE-POULENC), Luminal (BAYER)



Top

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

|

 

Advertisement
Tell us what you think about Web Health Centre - Send us your feedback
Copyright © 2012 WebHealthCentre. All rights reserved. Brought to you by