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  Nimesulide

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Musculoskeletal System
Category Non Steroidal Anti-Inflammatory Drug


Pharmacokinetics

Nimesulide is not a classical NSAID, it has weak action against prostaglandin synthesis [cox-2 inhibitor] but has a potent Anti-Inflammatory action.It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.



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Indications

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.



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Routes of Administration and Dosage

Oral dosage form in adults :100 mg b.i.d In children : 5 mg/kg/day in 2 or 3 divided doses.



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Contra Indications

Nimesulide is contraindicated in hypersensitivity, active peptic ulcer, moderate to severe hepatic disease and in pregnancy.



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Precautions

Those with Alcohol abuse, Colitis, Crohn's disease, diverticulitis, gastric ulcer, Diabetes mellitus, Hemorrhoids, Hepatitis, renal disease, rectal irritation or bleeding, Systemic lupus erythematosus and Tobacco abuse may have increased chance of adverse effects.



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Interactions

When Nimesulide is taken along with Cyclosporine, Digitalis glycosides, Lithium, Methotrexate, Phenytoin there will be elevated serum levels of these drugs and an increased chance of adverse effects may occur.



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Brand Names

Auroni (Aurobindo Pharma), Flexulid(Wander), Maxiflam(Karnataka Antibiotics), Maxulide(Max), Myonal(Uni-Sankyo), Nelsid(Ind-Swift), Neosaid(Blue Cross), Nilide(Le Sante), Nimbid(Astra IDL), Nimegesic(Alembic), Nimesel(Wave Pharma), Nimesul(Albert David), Nimfast(Indon), Nimind(Indoco), Nimobid(Mapra), Nimodol(Aristo), Nimoran(Perch)Nimsaid(Medley)Nimuflam(JK Drugs), Nimulid(Panacea), Nimuspa(Indoco), Nimusyp(Centaur), Nise(Dr Reddy's), Novogesic(Glenmark), Novolid(Brown & Burk), Orthobid(Nicholas Piramal), Pirodol(Menarini), Pronim(Unichem), Pyrnim(Saga Labs), Relisulide(Juggat Pharma), Remulide(Recon), Slide(Dee-Pharma).



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Pharmacokinetics | Indications | Contra Indications | Precautions | Interactions | Brand Names

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