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  Nifedipine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Cardiovascular System and Peripheral Vascular System
Category Calcium Channel Blocker


Pharmacokinetics

Given orally, it has high hepatic metabolism. Hence higher dose should be given by the oral route than by the I.V route. It is highly protein bound.



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Indications

Calcium channel blocking agents are used to relieve and control angina pectoris, to treat hypertension. Hypertension adds to the workload of the heart and arteries. If it continues for a prolonged period, the heart and arteries may not function effectively. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, cardiac failure, or renal failure. Hypertension may also increase the risk of MI. These problems may be less likely to occur if blood pressure is controlled. Also indicated in Arrythmias.



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Routes of Administration and Dosage

It can be given orally or sub-lingually. Orally : 5 mg 3 times daily with food, gradually increasing the dose upto 20 mg 3 times a day. The contents of a capsule are placed under the tongue for sublingual administration.



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Contra Indications

It is contraindicated in Hypersensitivity reaction, Acute MI, Hypotension, Lactation and Cardiogenic shock.



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Precautions

Allergies : Allergic reaction to nifedipine may occur. Pregnancy: Calcium channel blockers have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blockers cause birth defects, prolonged pregnancy, poor bone development, and stillbirth. Breast-feeding: Nifedipine passes into breast milk, but they have not been reported to cause problems in nursing babies. Older adults: Elderly people may be especially sensitive to the effects of calcium channel blockers. This may increase the chance of adverse effects during treatment.



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Interactions

Interaction with the following drugs have been reported: Acetazolamide, Amphotericin B, Corticosteroids, Dichlorphenamide, Diuretics, Methazolamide, Beta-blockers like acebutolol, atenolol, betaxolol, carteolol, labetalol, metoprolol, nadolol, oxprenolol, penbutolol, pindolol, propranolol, sotalol, timolol : Effects of both may be increased. In addition, adverse effects may occur if a calcium channel blocker or a beta-blocker is stopped suddenly after use together. Carbamazepine, Cyclosporine, Procainamide,Quinidine: Effects of these drugss may be increased if they are used together with calcium channel blockers. Digitalis glycosides : Effects of these drugs may be potentiated if they are used with calcium channel blockers. Disopyramide: Effects of calcium channel blockers on the heart may be potentiated.



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Brand Names

Adalat Oros (Bayer), Adalat Retard (Bayer), Angiblock (Alkem), Calbloc (Unisearch), Calcigard (Torrent), Calcigard Retard (Torrent), Cardipin (Intas), Cardule (Nicholas-Piramal), Depicor (Merck), Depin (Cadila Healthcare), Myogard (Searle), Myogard- LA (Searle), Myogard-OD (Searle), Nacten (Hindustan Antibiotics), Nicardia (Unique), Nicardia Retard(Unique), Nifidine (SPPL), Nifetal, Cipla), Niferil (USV).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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