Welcome, Guest    Sign in to Windows Live ID | Register  

  Industry Medical Portal |  Student Centre |  Sitemap |  Help 
FAQAbout Us |  Disclaimer & Legal |  Contact Us 

  Nalidixic Acid

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Urinary antiseptic
Category Antibacterial (Quinolones)


Pharmacokinetics

Nalidixic Acid when given orally is readily absorbed from the GIT, 80% is eliminated through the kidneys. Both active & inactive forms of Nalidixic acid is found in the urine.Concentration in urine is 20 to 50 times that in plasma.



Top

Indications

Nalidixic acid is used to treat infections of the urinary tract. It is highly effective against Gram negative Bacilli like E.Coli, Proteus. It has a weak action against Klebsiella and Aerobacter.Has a special place in treating ampicillin resistant shigella enteritis.



Top

Routes of Administration and Dosage

500 mgs to 1 gram every six to eight hours.



Top

Contra Indications

It is mainly contraindicated in infants upto 3 months of age and in those with convulsive disorders.



Top

Precautions

Adverse effects : the most important toxicity is neurological toxicity such as headache, drowsiness, vertigo, visual disturbances and occasionally seizures.Prolonged use has produced parkinsonism like symptoms, leukopenia and biliary stasis. When used in individuals with G6PD deficiency, they may develop hemolysis.



Top

Interactions

Interaction occurs with Anticoagulants : Patients taking Nalidixic acid with anticoagulants may have an increased chance of haemorrhage.Nitrofurantoin should not be used concurrently.



Top

Brand Names

Diarlop(Jagsonpal), Dix(PCI), Dixy(Rekvina Pharma), Enterodix(Albert David), Gramoneg(Ranbaxy), Nadix Acutab(Troikaa), Negadix(CFL), Ulix(Blue Cross).



Top

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

|

 

Advertisement
Tell us what you think about Web Health Centre - Send us your feedback
Copyright © 2012 WebHealthCentre. All rights reserved. Brought to you by