Oral lactulose is given for long-term treatment of chronic constipation. By its osmotic effect it retains water and softens the stool in 3-4 days. It is also has important indication in hepatic encephalopathy, where it reduces the NH3 concentration by 25-50%.

Oral dose : For Constipation in adults: 10 gms twice daily, adjusted according to patients need. For hepatic encephalopathy: 20-30gms thrice daily, it can be adjusted to produce 2-3 stools per day.

Contra Indications

Lactulose is contraindicated in Galactosaemia, undiagnosed abdominal pain or vomiting, organic constipation like intestinal obstruction, stricture, malignancy or hypercalcaemia. It should also not be used together with drugs that causes constipation like

Precautions

The use of laxatives in Colostomy or Intestinal obstruction or Ileostomy is normally avoided.

Interactions

Use of lactulose along with tetracycline may reduce the effect of tetracycline.

Brand Names

Duphalac(Duphar-Interfran), Lacsan(Unique), Livoluk(Panacea).

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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