Welcome, Guest    Sign in to Windows Live ID | Register  

  Industry Medical Portal |  Student Centre |  Sitemap |  Help 
FAQAbout Us |  Disclaimer & Legal |  Contact Us 

  Ibuprofen

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Musculoskeletal System
Category Non Steroidal Anti-Inflammatory Drug


Pharmacokinetics

Ibuprofen is phenylpropionic acid derivative. When given orally it is well absorbed and is highly plasma protein bound. It gets metabolised in the liver. It has a half-life of 2 hrs. About 10% gets excreted in the urine.



Top

Indications

Ibuprofen is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, during post operative and post traumatic period. It is given in chronic inflammatory condition like Rheumatoid arthritis, osteoarthritis.



Top

Routes of Administration and Dosage

Oral dose (oral suspension, tablets, ): For dysmenorrhoea in Adults : 200 to 400 milligrams (mg) every four to six hours as needed. For pyrexia in Adults: 200 to 400 mg every four to six hours as needed, in Children 6 months to 12 years of age: The dose is based on body weight and on the body temperature. For pyrexia lower than 102.5 °F (39.2 °C) the dose is 5 mg per kilogram (kg) of body weight. For severe pyrexia the dose is 10 mg per kg of body weight. For arthritis in Adults and teenagers: initially a total of 1200 to 3200 mg a day, divided into smaller amounts that are taken three or four times a day. Children 6 months to 12 years of age: The dose is based on body weight - initially a total of 30 to 40 mg per kg of body weight a day, divided into smaller amounts that are taken three or four times a day.



Top

Contra Indications

Ibuprofen is contraindicated in hypersensitivity, active peptic ulcer, moderate to severe hepatic disease and infants .



Top

Precautions

In conditions like Colitis, Crohn's disease, Diverticulitis,Gastric ulcer, Diabetes mellitus, Hemorrhoids, Hepatitis, renal disease, Rectal irritation or bleeding, Systemic lupus erythematosus,alcoholics and tobacco use: the chance of adverse effects may be increased.Ibuprofen has been rated as the safest NSAID by the spontaneous adverse drug reaction reporting system in UK.



Top

Interactions

Ibuprofen when used with Asprin gets displaced from its site . When used with lithium and Methotrexate, it increases their toxicity. Ibuprofen antagonises the effect of diuretics like Frusemide and Thiazide diuretics.



Top

Brand Names

Alfam-400(Albert David), Arfen(Centaur), Bren(Kopran), Brufen(Knoll Pharma), Embru(Malladi Drugs), Emflam(Merck), Febrilix(Knoll Pharma), Fenspan(Smithkline Beecham), Ibrumac( Macleods), Ibucin(Samir Remedies), Ibugesic(Cipla), Ibugin(Glaxo Pharma), Iburin(Unisearch), Ibusynth(Astra IDL), Myofen(Nulife), Nuren(Dabur), Norswel(Cadila Healthcare), Reducin (Unique), Tabalon(Hoechst Marion Roussel), Tricofen(Max).



Top

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

|

 

Advertisement
Tell us what you think about Web Health Centre - Send us your feedback
Copyright © 2012 WebHealthCentre. All rights reserved. Brought to you by