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  Doxycycline

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Antibacterial-Tetracycline.


Pharmacokinetics

Doxycycline is a high plasma protein binding drug .It has a longer half life after oral administration. It's plasma level is not altered by renal disease hence can be used in the presence of a renal impairment.It is primarily excreted in faeces as conjugate.Half life is 18 to 24 hrs.



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Indications

Doxycycline is a semisynthetic tetracycline. It is bacteriostatic in action, acts against Chlamydia trachomatis, mycoplasma, vibrio cholerae, brucella, yersinia pestis, borrelia recurrentis and rickettsial infections. It also acts against Plasmodia.



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Routes of Administration and Dosage

Oral ; 200 mgs initially, then 100 to 200 mgs O.D.



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Contra Indications

Contraindicated in children under 12 yrs of age, SLE, pregnancy, lactation, and in patients with hypersensitivity to teracyclines.



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Precautions

Patients with hepatic disease may have an increased chance of adverse effects if they use Doxycycline.



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Interactions

Reduced absorption is seen with Antacids, Calcium supplements, magnesium salicylates .Oral contraceptives containing estrogen: it may decrease the effect of contraception and increase the chance of unwanted pregnancy.



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Brand Names

Biodoxy(Biochem), Ceedox(Shalaks), Codox(Comed Chemicals), Dedoxyn(DWD Pharma), Doxy (Reddy's), Doxy-1 (Sterling Labs), Doxy 24 (Vilco), Doxyclin(Inga), Doxycycline(Jagsonpal), LAA (Bombay Tablets), Lydox(Lyka), Microdox( Micro Labs), Nudoxy(Nulife), Tetradox(Stancare), Vivocycline(IDPL).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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