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  Co-trimoxazole

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Antibacterials


Pharmacokinetics

The half life is about 6 - 10 hours. 70% is excreted in the urine and about 80% of this is unchanged.



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Indications

Sulfonamide and trimethoprim combinations are used to treat respiratory,Genito-urinary and ENT infections. Sulfadiazine and trimethoprim combination is used to treat urinary tract infections. It is also used for the prevention and treatment of Pneumocystis carinii pneumonia (PCP).



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Routes of Administration and Dosage

Oral dose : For bacterial infections: Adults and children 40 kilograms (kg) of body weight and over : 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim every twelve hours. Infants less than 2 months of age : Use is not recommended infants 2 months of age and younger. Children less than 40 kg of weight: Dose is based on body weight, 20 to 30 mg of sulfamethoxazole and 4 to 6 mg of trimethoprim per kg of body weight every twelve hours. For the treatment of Pneumocystis carinii pneumonia (PCP): Adults and children older than 2 months : Dose is based on body weight, 18.75 to 25 mg of sulfamethoxazole and 3.75 to 5 mg of trimethoprim per kg of body weight every six hours. For the prevention of Pneumocystis carinii pneumonia (PCP): Adults : 800 mg of sulfamethoxazole and 160 mg of trimethoprim once a day. There are several dosing regimens available that might be chosen from. One dosing regimen is 375 mg of sulfamethoxazole and 75 mg of trimethoprim per square meter of body surface two times a day, three times a week on consecutive days (e.g., Monday, Tuesday, Wednesday). For injection dosage form: For bacterial infections: Adults and children older than 2 months The usual total daily dose is 40 to 50 mg of sulfamethoxazole and 8 to 10 mg of trimethoprim per kg of body weight. This total daily dose may be divided up and injected into a vein every six, eight, or twelve hours. Infants less than 2 months of age : Use is not recommended.: For the treatment of Pneumocystis carinii pneumonia (PCP): Adults and children older than 2 months : The usual dose is 18.75 to 25 mg of sulfamethoxazole and 3.75 to 5 mg of trimethoprim per kg . This is injected into a vein every six hours.Infants less than 2 months of age : Use is not recommended.



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Contra Indications

Contraindicated in renal and hepatic disease, lactation, haematological disorders and in infants below 2 months.



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Precautions

In Anemia or other haematological disease or Glucose-6-phosphate dehydrogenase (G6PD) deficiency: Patients with these problems may have an increase in adverse effects affecting the blood cells. In Renal disease or hepatic disease : Patients with Renal and/or hepatic disease may have an increased incidence of side effects. In Porphyria: This drug may precipitate an attack of porphyria.



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Interactions

With Acetaminophen, Amiodarone, Anabolic steroids, oxandrolone, oxymetholone, stanozolol, Androgens, Antithyroid agents, Carbamazepine, Carmustine, Chloroquine, Dantrolene, Daunorubicin, Disulfiram, Divalproex, Estrogens, Etretinate, Gold salts, Mercaptopurine, Naltrexone, Oral contraceptives containing Estrogens, Valproic acid : Use of sulfonamide and trimethoprim combinations with these drugs may increase the chance of adverse effects affecting the liver. Oral Antidiabetic agents : Use of oral antidiabetics with sulfonamide and trimethoprim combinations may increase the risk of blood disorders. Methenamine :Use of methenamine with sulfonamide and trimethoprim combinations may increase the chance of adverse effects of the sulfonamide.



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Brand Names

Actiprim(Synthiko), Bactrim(Piramal Healthcare), Ciplan(Cipla), Cosulf-p(Blue Cross), Fortrim(BDH), Meditrim(Medico), Rizol(Bombay Tablets), Septran (Burroughs Wellcome), Sepmax (Burroughs Wellcome) Stan Kid(Sol), Synastat (Roussel)Timizol(A) (Plethico), Wypal(Jagsonpal).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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